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Influence of hydroxyapatite granule size,porosity, and crystallinity on tissue reaction in vivo. Part A: synthesis,characterization of the materials,and SEM analysis 下载免费PDF全文
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Periodontitis and Non‐alcoholic Fatty Liver Disease,a population‐based cohort investigation in the Study of Health in Pomerania 下载免费PDF全文
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Dealmy Delgadillo Olivier Barbier Gerardo Sierra Jose L. Reyes 《Fundamental & clinical pharmacology》2014,28(2):170-179
End‐stage renal disease is a cause for death worldwide. Renal transplant is a therapeutic alternative, restricted by the scant number of donors. Function of the donor kidney is under risk of adverse circumstances such as fibrosis, where profibrotic effect of transforming growth factor beta 1 (TGF‐β1) plays a key role. Efforts to diminish risks of damage in the remnant kidney of the donor are required. Vitamin A represents one alternative. It has beneficial effects on some nephropathies, mainly those related to oxidative stress. It also participates in normal intrauterine renal development. We studied the effect of all‐trans retinoic acid (ATRA), active form of vitamin A, on postnephrectomy compensatory growth, in male or female rats. Compensatory growth and renal function were evaluated on four experimental groups: Control without treatment (CTL), ATRA‐treated intact rats (CTL + RA), nephrectomized rats (NFX), and ATRA‐treated nephrectomized rats (NFX + RA). We evaluated glomerular function (inulin clearance), tubular function (fractional excretions of sodium and potassium), and urinary flow. Renal mass was also estimated. In ATRA‐treated animals, compensatory growth was higher than in nephrectomized rats without treatment. Hyperfiltration after nephrectomy was less intense in ATRA‐treated female than in male rats. In tubular functions, effect of ATRA was more evident in female than in male rats. Glomerular expression of TGF‐β1 was lower in ATRA‐treated animals than in controls. ATRA reduced intensity and duration of compensatory changes after nephrectomy, improving recovery. 相似文献
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Josué Hernando MD DDS PhD Pablo Aguirre MD Antonio Aguilar-Salvatierra DDS PhD Ignacio Osoitz Leizaola-Cardesa DDS PhD Ainhoa Bidaguren MD Gerardo Gómez-Moreno DDS PhD 《Journal of surgical oncology》2020,121(2):244-248
The aim was to evaluate sentinel node detection capacity by means of a magnetic probe in 11 patients with oral squamous cell carcinoma at stages T1-T2 received submucosal injections of a superparamagnetic iron oxide contrast agent (SPIO). A magnetic probe was used for sentinel node biopsy. The use of SPIO and magnetic probes in the early stages of oral cancer may offer an alternative to conventional radioisotope techniques and/or elective neck dissection. 相似文献
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Gabriel López-Ramírez Rodolfo Sánchez-Zavaleta Arturo Ávalos-Fuentes Juan José Sierra Francisco Paz-Bermúdez Gerardo Leyva-Gómez José Segovia Vila Hernán Cortés Benjamín Florán 《Synapse (New York, N.Y.)》2020,74(3):e22139
CB2 receptors (CB2R) are expressed in midbrain neurons. To evidence the control of dopamine release in dorsal striatum by CB2R, we performed experiments of [3H]-dopamine release in dorsal striatal slices. We found a paradoxical increase in K+-induced [3H]-dopamine release by CB2R activation with GW 833972A and JWH 133 two selective agonist. To understand the mechanism involved, we tested for a role of the D2 autoreceptor in this effect; because in pallidal structures, the inhibitory effect of CB1 receptors (CB1R) on GABA release is switched to a stimulatory effect by D2 receptors (D2R). We found that the blockade of D2 autoreceptors with sulpiride prevented the stimulatory effect of CB2R activation; in fact, under this condition, CB2R decreased dopamine release, indicating the role of the D2 autoreceptor in the paradoxical increase. We also found that the effect occurs in nigrostriatal terminals, since lesions with 6-OH dopamine in the middle forebrain bundle prevented CB2R effects on release. In addition, D2–CB2R interaction promoted cAMP accumulation, and the increase in [3H]-dopamine release was prevented by PKA blockade. D2–CB2R coprecipitation and proximity ligation assay studies indicated a close interaction of receptors that could participate in the observed effects. Finally, intrastriatal injection of CB2R agonist induced contralateral turning in amphetamine-treated rats, which was prevented by sulpiride, indicating the role of the interaction in motor behavior. Thus, these data indicate that the D2 autoreceptor switches, from inhibitory to stimulatory, the CB2R effects on dopamine release, involving the cAMP → PKA pathway in nigrostriatal terminals. 相似文献